Search The KBzine.ement, try accenting with rich purple or golden hues. T: 254-523-9605 E: Jamie.Brooks@dreammaker bk.com W: www.dreammaker-remodel.com. Click image to watch the video Electrolux has just released eight superb mini video clips about each of the Electrolux Design Lab finalists. From a gel fridge to a dishwasher that composts food left on your plates, they really do make you wonder why no-one's thought of them before. Check them out on the website and then make sure you see them for yourself at 100% Design, which is taking place at London's Earls Court from 23rd to 26th September 2010.

Request (PDF) Introduction to Nano. On ResearchGate, the professional network for scientists. This self-confessed introduction provides technical administrators and managers with a broad, practical overview of the subject and gives researchers working in different areas an appreciation of developments in nanotechnology outside their own fields of expertise.

Www.electroluxdesignlab.com.e is offering a free five-year parts and labour guarantee on its black or white WA72145 and WA72145 BK washing machines and D72325 and D72325 BK condenser dryers. T: 0208 247 3980 Tile Depot has launched several new tile ranges. They include metallic finishes, natural stone and stone-look ceramics, marble effect, porcelain with a natural slate. Around 40% of SMEs in the UK - two million businesses - do not keep adequate records, even though they are legally bound to keep them, to make sure they make a correct income tax or corporation tax self assessment return. Failure to take reasonable care in record-keeping leads to a loss of around £6.5billion in tax every year. Products will be showcased in the Innovations Centre at the kbb London exhibition are:[TRIMTO] A BK InnoVent Britannia Living Caple CDA De Dietrich Appliances Fisher & Paykel Appliances Franke Grohe Hafele Hansgrohe Hoover KitchenAid Roman S-Box Scholtes Sensio Taptile Teuco The Pure H20 Company Whirpool 'We are delighted to inspire and s.bour guarantee on any one of four washing machines and dryers.

These include the WA72145 and WA72145 BK washing machines and the D72325 and D72325 BK condenser dryers; available in either a classic white or stylish black finish. Ruth Ferguson, Gorenje's Marketing Manager, says: 'This promotion has been very popular, and by running it again we are. Building on the successful 2010 launch of T BK rigid built kitchens, six new ranges are now introduced. Painted ash timber doors in a traditional style with tongue & groove effect centre panels lead the way in creating a luxurious look without busting the budget. Natural oak and painted Ivory finishes are available from stock with 13 other. Welcome to the KBzine It takes something like the story in this week's news of the worker crushed to death by three tonnes of stone slabs to remind us that workplace health & safety regulation is actually there for a reason. It's sad that the overzealousness of some has served to make the rest of us take our eyes off t.

Welcome to the KBzine We've heard a great deal about the Olympic Village where they'll all be staying, the new stadia and aquatics centre where the sports men and women will be displaying their prowess and the surrounding parklands that have been established for them, as well as visitors, to enjoy, but nowhere have I seen an. Welcome to the KBzine It's all very well getting your kitchen, bathroom or bedroom into one of the sets on a TV programme but it only really does you any good if people know that you're the manufacturer. Some interested viewers may take the trouble to 'phone the TV channel to find out, but most won't bother. Lee Moss FCCA, BA (Hons) joins kitchen manufacturer BKoncepts as Financial Director.

He will oversee all financial matters within BKoncepts and comes to BK from Nabarro Poole Chartered and Management Accountants.[TRIMTO] Lee graduated from Liverpool John Moores University in 2000 with a BA (Hons) in Accounting & Finance. E: sales@amckitchensupplies.co.uk W: www. Michael, please visit his Just Giving page at: www.justgiving.com T: 02 W: www.d bkdesigns.co.uk T: 0121 765 3629 W: www.merewaykitchens.co.uk. Gish Serial Code on this page.

Franke has enlarged its range of highly popular decorative cooker hoods with the launch of its new Maris model in sleek black glass. In a stylish design with 90cm wide flat front and rounded corners, this is the only hood in the range which, when in recirculatory mode, does not require a chimney so it can be fitted to a wall compactly, similar.isplays are hardwearing and fully functional, featuring working appliances from Gaggenau, Wolf and A BK, which will be utilised for cooking demonstrations in the near future. Throughout the showroom, the company has created displays, which blur the lines between furniture design and kitchen design. The first display to greet customers provides a.g Compactor Series * Fisher & Paykel: 90 litre Built-in Single Oven OB60SL11DCPX1 * Caple: DD930 BK Induction Downdraft * Mereway Kitchens: Modern Classic Collection from English Revival * Quooker: Quooker Fusion with Combi System * Miele: Miele Generation 6000 DGC 6800 XL Combination Steam Oven Kitchen Customer Service of the Year * In every.

Uform has added to its award wins with two more accolades at the 2015 BKU awards which took place in London's Madame Tussauds on 25th June. As a finalist in four individual categories, the company now boasts Mark McNulty as Best Sales Representative of the Year together with being highly commended in the overall Kitchen Brand of the Year category. The bars some people fitted in their living rooms back in the 70s were all very well in terms of keeping everything in one place, but they didn't exactly look wonderful or create a good impression for visitors who weren't there to party, did they? Terence Ball Kitchens has come of with a great solution, as our picture illustrates. Yes - everyt.t hi-tech manufacturers of lifestyle ceramics solutions, was voted 'Best Sanitaryware Brand' at the BKU Awards 2016.

'It is an honour to receive the award for 'Best Sanitaryware Brand' at the BKU Awards 2016,' says Abdallah Massaad, Group CEO at RAK Ceramics. 'RAK Ceramics has enjoyed 25 years of ceramics expertise and our products feature in so.Ripples founder and chief executive Roger Kyme has been awarded a Lifetime Achievement award at the BKU awards. Roger has spent an impressive 40 years in the bathroom industry with a career that spans the Atlantic. His passion to run his own showroom brought him back to the UK and in 1988 he opened the doors to his own bathroom showroom 'Ripples.which ensures that extraction continues for up to 10 minutes after cooking is complete. The DD903 BK also benefits from perimetrical extraction, which lowers sound levels and increases the pressure for improved motor performance. Caple managing director Danny Lay says: 'You can use this model's tilt position, which offers discreet and unobtrus. Welcome to the KBzine First, please accept my apologies for the late arrival of this issue of KBzine.

Unfortunately I’ve been grappling with that hazard of modern living – running water! Living at the foot of Epsom Downs means my water is i. Welcome to the KBzine Gas Safe Register is calling for private renters to be more gas safe as research reveals that 2.7million tenants are at risk from dangerous gas appliances. The campaign launched yesterday and is supported by Dominic Littlewood, (from TV shows Fake Bri. Welcome to the KBzine The Government has today given the go-ahead for Buckingham Palace to undergo a 10-year overhaul, costing some £370 million, with ‘essential works’ to include replacing electrical wiring, water pipes and the heating system (i.

Welcome to the KBzine If you’ve been reading this column since John Austen & I took over the reins from our friends Richard and Debbie Schwarz, you’ll already be aware that I’m a big advocate of industry associations – not only from a c. Welcome to the KBzine Happy Black Friday to you! I can't quite make up my mind whether this buying extravaganza is something retailers love or dread.

Yes - in terms of sales, it can make a huge difference to the end of year figures, but in terms of logist. Welcome to the KBzine What do you think of kitchen islands? As a retailer, do you like them and do your customers. Do they try to shoehorn them into too tiny a space or is it a case of 'take them or leave them'? Or as a manufacturer, are you happy about produc. Welcome to the KBzine Welcome to the first 2017 issue of KBzine.

I hope you had a good break and that you are one of the few people who managed to avoid that dreadful virus that's had the majority of us laid low with rag. Welcome to the KBzine I was lucky to have been able to attend the CIH suppliers lunch at the Dorchester this week - not only because it was a jolly event and a nice lunch at a great venue, but also because it's always good to be able to chat to folk 'at the sharp e. Welcome to the KBzine Fleet managers are being urged to make additional licence checks for temporary hires and staff delivery drivers covering the Christmas & New Year sales period to ensure that drivers are qualifi. Welcome to the KBzine Waterwise and Ideal Standard commissioned a water usage report at the end of last year, the results of which, reveal that more of us are actively using less water - up to 88% of respondents in 2016. Welcome to the KBzine Have you seen the video that's gone viral on social media, of the OaSense shower that switches itself off when whoever's in the shower, moves out from underneath? Forgive me if this type of gadget is old hat (I've never come across one before) but what a great idea! I'd always thought t.

Welcome to the KBzine Well. May I start by wishing you a Happy Thomas Crapper Day!

My thanks go to Fiona Pavely of Shelan Communications for reminding me that today's the day for counting our blessings for the birth of Thomas Crapper (who died this day in 1910). If you're unfamiliar with the name, Mr Crapper i. Welcome to the KBzine Wednesday's Office for National Statistics announcement that UK employment reached 74.6% in the last quarter of 2016 - the highest rate since such records began in 1971, while unemployment remained at its record low since 2005 on 4.8%, compared w. Welcome to the KBzine Wednesday’s Office for National Statistics announcement that UK employment reached 74.6% in the last quarter of 2016 – the highest rate since such records began in 1971, while unemployment.

Welcome to the KBzine While many in this industry have been enjoying themselves out at ISH this week, John Austen and I have been at a cleaning show at ExCel in London's Docklands. The KBB sector was never far from our hearts and minds however, particularly so since all the wonderful things this industry. Welcome to the KBzine Last week's Office for National Statistics announcement that UK employment reached 74.6% in the last quarter of 2016 – the highest rate since such records began in 1971, while unemployment remai. Welcome to the KBzine The first time I ventured into Ecobuild I was absolutely blown away by everything on offer and it struck me that this was the way, we as human beings, need to live in the future, if we're to make the most of the Earth's valuable resources. I often say when visiting shows related to the KB. Welcome to the KBzine I know people say you shouldn't do it as it prevents you from getting off to sleep, but I tend to do it anyway as I find it helps me relax while I'm warming up the bed so when I do shut down, I'm warm and cosy and ready for sleep and can avoid those minutes of shivering a little (which c.

Welcome to the KBzine One of the things I mentioned in last week's leader was that I'd been in discussions with the Domestic Cleaning Alliance's director Stephen Munton about some of the problems caused to his members when KBB appliances, fixtures and fittings aren't designed with cleaning in mind. Welcome to the KBzine Around three years ago I was having trouble with a builder who was due to fix a couple of cisterns (you may remember, the one who instead of fixing the cisterns, painted my already newly-painted 'Contemporary' dining room wall and my equally neutral, newly-painted kitchen, bright yellow. Welcome to the KBzine As the years go by, we're seeing more and more women learning one of the building trades, running their own businesses and making an excellent living out of what has traditionally been 'a man's job'. Since the take-up of a trade by women is something that's relatively new, I was surprise.eriors, Leeds Bower Willis Designs, Shipston on Stour B&H Kitchens, EC1 London (Cooking studio) BK Nolte Contracts, SW1 London Concept One, Hertfordshire Cucucine Homes & Kitchens, Oxfordshire BK Nolte Contracts, Wrexham Clearly Interiors, Lancashire Day True, SW10 London Day True, W9 London Eggersmann Design, SW6 London Freestyle Kitchens. Welcome to the KBzine Kitchen gadgetry and innovations have certainly made it into the nationals over the past couple of weeks, haven't they? One that surprised me, was the article about how the use of a blue plastic ball-like object, popped in with the wash, reduces the need for laundry powder/liquid and thr. Welcome to the KBzine On Sunday, a record 40,000 dedicated souls (or should that be so many thousand soles?) pounded the streets of England's vibrant capital city in the 2017 London Marathon.

Many were elite runners for whom this type of effort is a way of life but tens of thousands of them saw it as a life c. Welcome to the KBzine I'm an avid MasterChef fan although I think that the fact that I watch it in bed, laptop-on-chest, until I fall asleep, isn't the only thing that makes me odd. Unlike most Brits, it doesn't inspire me to cook - although I'll confess that have bought several celeriacs (to puree, then swis. Welcome to the KBzine The focus in recent years has been so much on ensuring we’re not bringing anything into the country which (or who) shouldn’t be here, that it appears we’ve lost focus on the awareness that others might want to take stuff out! Vehicle leasing specialist Arval ( www.se. Welcome to the KBzine It's funny, isn't it? We work in the KBB industry but unless we're involved in a makeover or are removing an old appliance/ripping out an unwanted bathroom or kitchen, we always picture everything as being in perfect condition.

Our industry spends a fortune on designing new. Welcome to the KBzine Following on from last week's leader in which I shared the sad story of a tradesman who met his demise as a result of a lapse in safe working procedures, I'm delighted to see that the UK'S safest house builders have been honoured by the NHBC, which has announced the winners of.

Welcome to the KBzine Following on from last week's leader in which I shared the sad story of a tradesman who met his demise as a result of a lapse in safe working procedures, I'm delighted to see that the UK'S safest house builders have been honoured by the NHBC, which has announced the w. Welcome to the KBzine With the Election results now in, the Kitchen, Bathroom, Bedroom Specialists Association's national chair Richard Hibbert has been considering the outlook for the sector. Richard says that while much of the focus of the election has been on investment in the NHS, education and. Welcome to the KBzine Like everyone else, I've been distressed by the devastating news about Wednesday's fire at London's Grenfell Tower. I know that every day, people are injured or killed in their masses throughout the world and like most of us, I hurt for them all.

With my daughter working for. Welcome to the KBzine We Brits are regularly using social channels to find inspiration and show off our cooking accomplishments - with 57% of us saying we eat more adventurously than ever before as a result - either to impress our followers, or as a result of resolving to copy something we've seen o. Welcome to the KBzine I made a conscious decision not to mention it in last week's KBzine but I've been thinking a lot about the impact the announcement will have made. Yes - the naming of the brand of fridge freezer purported to have been the cause of the Grenfell Tower fire has to be every manuf.operation, fought off tough competition to win Best UK Independent Bathroom Retailer at last week's BKU Awards. Wholesale Domestic is the first Scottish company ever to win the award.

'This award, based on the votes of industry peers, reflects the quality of service we provide in all aspects of our offering, from sales, to warehousing and distri. Welcome to the KBzine I visited a friend this week who was having work done on her bathroom. I knew the people who'd replaced her electric shower a couple of years ago and had expected that they'd done a good job, so was disturbed to join my friend at the consumer unit, as the electrici.s tells us it is delighted to have been voted Britain's Best Bathroom Furniture Brand at the recent BKU Awards. As a leading British manufacturer of bathroom furniture, Utopia has consistently made the shortlist for the Best Bathroom Furniture Brand category in the annual award scheme run by BKU (Bathroom & Kitchen Update) but this is the fi. Welcome to the KBzine It takes a lot to make me cross, but sat in a queue of cars with a boot-full of garden waste for dumping at my local civic amenity tip, is not how I like to spend a hot sunny day. I'd not expected it to be busy either, since it was late morning, mid-week. Welcome to the KBzine Having received a press release referring to Legionella Awareness Day and deciding to look a little more deeply into the issues, I came across a report in the journal Eurosurveillance.

Compiled from annual data submitted by 29 EU/EEA countries to the European Legionnaires' D. Welcome to the KBzine 'Appliances Home Alone (safely)' was how the release was headed up and although my first thought was that I'd be preaching to the converted by mentioning it here, my subsequent realisation that I'd not got around to registering my fridge freezer - purchased several months back - despi. Welcome to the KBzine Information technologies, smart data, digitisation and the Internet of Things have revolutionised many activities in our daily lives. For example, 15% of UK retail spending is now online, totalling £52 billion in 2015. EBay hosts 150 million active trades at any one time and l. Welcome to the KBzine Having observed washing machines being delivered and even carried upstairs, and seen the sweat (and sometimes blood and tears) that results, I know how heavy they can be.

There's never really been a way around the problem, although a friend of mine did try removing the concrete block. Welcome to the KBzine John & I are about to take our annual Summer break; this will be the last issue of KBzine until our September 8th edition. One of the things I tend to do over the warmer months is take part in small music/wellbeing/personal development festivals that bring out the inner hippie. Welcome to the KBzine Welcome to our first post-Summer-break issue of KBzine. If you managed to get away or simply take some time off, I hope your batteries have been recharged too. Such a lot seems to have happened since we've been away but sadly, very little of it in our country has involved consistent w.

Welcome to the KBzine With the weather the way it's been lately, I'm sure I'm not the only one in need of a bit of a fillip and if we can't enjoy an Indian Summer then at least we can be inspired by the interiors extravaganza we're about to experience around the Capital, in terms of the London Design Fair. Welcome to the KBzine London Fire Brigade's latest campaign is going to impact quite heavily on this industry's appliance manufacturers. Its 'Don't turn your back on fridge fire risk' and 'Total Recalls' messages have been picked up by Which?

- something that's likely to lead to demands from buyers in st. Welcome to the KBzine Had to have a chuckle at the findings of the recent survey by Samsung Electronics (www.samsung.com/uk). Having surveyed 2,000 men and women in the UK, the company has revealed the UK's most annoying domestic habits - the top three being: 1) Food left in the fridge: 83% of.

Welcome to the KBzine I've had an interesting response to last week's leader from my good friend Stephen Munton of the Domestic Cleaners Alliance (you can read it below). It has taken me back through a history of the electrical appliance industry that I hadn't known existed, because of the long break betwe. Welcome to the KBzine As someone who's habitually found it difficult to employ an affordable tradesperson who's good at his or her trade and who can 'fit me in', a press release I received this morning really hit home. Heating and boiler specialist Warm.co.uk is warning that the UK is in danger of running. Welcome to the KBzine Sadly, our industry has made it into the press again this week, in a way that most of us wish it hadn't. The news that there are apparently some 1million tumble dryers in our nation's homes that pose a fire risk, has made many of us wonder whether our own appliances are safe.

Welcome to the KBzine Sadly, another couple and their children have had their lives changed drastically thanks to a tumble drier fire which devastated their home and killed their cats. And as they weren't insured, it's not just psychological issues they'll have to deal with. I gather the appliance was. Welcome to the KBzine Years ago, as assistant editor on Baker's Review, I was given a Dualit 4-slice toaster and a Warburton loaf at a press launch as a 'thank you for coming' gift.

The toast was soon gone but the toaster went on for years, having pride of place in my kitchen where it was probably the most. Welcome to the KBzine I used to work with a chap who'd disappear off to the loo every morning with a newspaper, which - no doubt - he'd read whilst in the loo as he was always gone for around half an hour. I wonder if he'd have stayed in there for as long, had he been faced with the view offered by the lat. Welcome to the KBzine John Austen was lucky enough to attend the business aviation show in Las Vegas a few weeks back with a colleague who produces an e-zine for that industry. He posted a picture on Facebook, of him strapped into an aircraft seat, captioned something like: 'The nearest I'll ever get to fl.

Welcome to the KBzine I almost didn't click on the link to the full article but curiosity soon got the better of me. And the first thought that popped into my head as I read was: 'Why?' If you don't know what I'm talking about, a group of youths wasted the West Midlands Fire Service's already stretched r. Welcome to the KBzine A five-metre high Christmas tree, made from 600 reused green plastic bottles, is being lit-up over the holiday period in Bognor Regis town centre, to highlight the need for us to recycle as much as possible. I thought I'd help spread the word, to those who aren't likely to venture int.

KBzine: the original kitchen and bathroom industry e -news - since 2002 [ISSUEDATE] We strongly recommend viewing KBzine full size in your web browser. Click our masthead above to visit our website version. Welcome to the KBzine While producing this latest issue of KBZine I wondered where everyone would be whilst reading it. Whether, because of the unusual arctic weather conditions that have brought much of Europe to a virtual standstill, you've managed to make it into your place of work yet or whether you're picking up your work emails and.ing Screwfix, Kwik Fit and Senate Electrical on Farnham Road Trade Park, part of the renowned, world -class Slough Trading Estate.

The new Tile Depot store opened on 4th January with a bigger, better showroom to make shopping easier and double the warehousing capacity for more stock. In store, more displays flaunt the popular retailer's comprehen.

The expert design team at Evitavonni predicts some interesting design trends for 2010. Design -savvy consumers can expect to see several key themes emerging including kitchen -intelligence, colourful confidence, purposeful bespoke and modern eastern. These four themes work together to provide interiors that are intuitive, brighter, more lifestyle s.pecified on aluminum and 20% when specified on white cabinets.

The Phoebe kitchen features a high -gloss slab -style door in bright white with an ultra -modern 2mm aluminum effect trim. An alternative aluminum profile strip can be specified for a more minimalist effect, featuring concealed handles or a choice of touch -opening systems.

Cabinets are.ny, Lux Elements is already one of the first choices in UK commercial wetroom environments. The easy -to -fit systems mean that both retailers and installers can offer wetrooms to the consumer market with confidence. The comprehensive range of wetroom kits offered by Simpsons provides for both level access and step -up situations and contain everyt.exposes the industry to further possibility of merger and acquisition opportunities, as well as anti -trust scrutiny.

The competitive landscape section provides a closer examination of this situation. This 153 -page report includes the most recent information on the domestic market, global market and overseas growth opportunities.

Updated quarterl.rowth, although it remains a small sector of the overall sanitaryware and bathroom furniture market - accounting for around 10% at the present time. It is also a small market when compared to the kitchen worktop market - being the equivalent of around 10 -11% of that market.

In the housing market there has been growth in the number of second bathroo.sure to suit the space, a matching shower tray, high quality thermostatically controlled shower and - for the perfect finishing touch - choice of beautifully chrome -finished bathroom accessories. 'We have excellent relationships with our customers and are always open to their feedback for ideas that can help improve service and make life easier.tant than ever to give customers something back. That is why we have negotiated this exclusive three -year Airmiles deal with The Mileage Company. 'It is the first incentive scheme of this magnitude within the industry and provides BCG with a distinct advantage over its competitors. As a business -to -business scheme, BCG is breaking new ground. Companies in the builders' merchanting and home improvement market, has bought a 49% stake in Leeds -based natural stone tile distributor, The Mosaic Tile Company, for an undisclosed sum.

The Mosaic Tile Company, which includes trading divisions; Romana Tile Company, Verona Stone Company and Stone Nation, was founded by Adrian Hinchliffe in 2000. It's the super intelligent, freestanding washer that is equally able as a powerful stand -alone unit or as the stunning centrepiece of a total laundry room concept.

Styled in classic black and carrying an 'A+' washing performance, Maytag's versatile MWA 0714FBC washer can smoothly fit into your lifestyle in any way you wish. The laundry room co. Kitchen specialist, Franke, has recently appointed two new distributors - Leaker Direct and Cooper Callas.

Both distributors offer Franke's full range of sinks, taps, hoods and kitchen solutions, and Franke is confident that both companies will deliver high service to meet the exacting standards of Franke. Leaker Direct is Scotland's large.ar with this early announcement of the date and venue.' [TRIMTO] T: 23 E: info@bathroom -association.org.uk W: www.bathroom -association.org. Problem, but we all know that it's the right thing to do.

Everyone has a different way of doing it - bags, or boxes in the kitchen, in the garden, squashed into a cupboard until the next trip to the supermarket. Even for those lucky enough to have kerbside collections, where do you store your recycled materials until the collection date? Wouldn't.pport he has given over the years to skills training, education and qualification in, both furniture -making and design creativity. In July 2009 he was awarded the medal of the Order of the League of Mercy for his support of the specialist teaching charity Dyslexia Action - a cause dear to his heart as he is dyslexic himself. The Medal was presented.n Joseph, the former managing director of Allied Kingswood, has taken a controlling interest in Kent -based Theobald's Distribution. Stephen, who has been acting as a consultant to Theobald's since September 2009, becomes the CEO of the company and will be working with present directors Jamie Gardiner (Operations Director) and Steve Brooks (Sales.ome (after space heating) and about 25% of the household's annual energy bill is from heating water - so reducing your water wastage really will save money, energy and water and reduce your carbon emissions, thereby helping to protect our local water supplies, plants and animals. This week is the 20th anniversary of World Water Week, so what bet.the globe, KBzine can help you achieve this by introducing your company and its products every week - direct to the reader's Inbox.

And with the exhibition season fast approaching why not ask us how KBzine can help maximise your efforts reaching the market place? Yours, Jan Hobbs.of the catches – the heir and the spare.

The part number we originally found online is: #21 -284. If you are able to forward my email directly to Showerlux, which would be much appreciated.

Thanks, Mrs Pat Wenger T: 416 691 -8235 E: wenger8235@rogers.com Ed: Can anyone help this reader please? Behind, while the Shaker style is seeing a surprisingly strong resurgence. Shades of whites and off -whites will be the most common kitchen colors in 2010, while brown, beige, and bone hues will also be popular. Cherry on top: Cherry will remain the most popular wood for kitchen cabinetry, followed closely by maple, while alder increases in u.g home appliance brand Belling, has announced the launch of a new interactive digital cookery guide - the Media Chef. Ideal for cooks of all abilities, the Belling Media Chef is the perfect kitchen accessory for those looking to create a culinary masterpiece. Pre -loaded with 48 cook -a -long demonstration recipes including three exclusive recip. The Baumatic brand is being strengthened further thanks to an exciting cross -marketing partnership with chocolate manufacturer Galaxy.

The two companies are teaming up for a series of competitions appearing in several high -circulation consumer titles, across both magazine and online formats, including Womenandhome.com and Prima. The competitio.

Financial times we are planning for a very bright future.' T: +44 (0) 1934 744466 E: sales@vado -uk.com W: www.vado -uk.com.in Air Systems, a leading indoor air cleaner manufacturer, to launch a new National Sleep Foundation -branded air purification system specifically designed for the sleep environment. The National Sleep Foundation Bedroom Machine by Austin Air is making its debut at the Big Sleep Show in Washington, DC today. Developed and designed by Austin Air.t offering continuity of supply on all products. To support the launch of the new brand, an eight -page leaflet and a trade branded point of sale dispenser box will communicate the products and sales information. The current product portfolio includes soft close thermoset toilet seats, a dual flush concealed cistern, bath panels, showers, taps.t, traditional convection heating, top heat, bottom heat and fan with ring heater and bottom heater - ideal for pizzas.

Rated A for energy efficiency, the 601IE3Ta also features an easy -clean ceramic induction hob with four zones - two 21cm and two 16cm - for quick and efficient hob -top cooking using a minimal amount of energy. The oven has a.ined valuable insights from roles which include training as a painter and decorator, running a multi -site builders merchant, being responsible for training and even running his own contractor business. 'Kaldewei has a fantastic range of products and I look forward to steering the sales team towards achieving the first class results that the prod.ra, Bryan Lovewell, and Support & Development Executive, Mike Floodgate, were host to: Hu Beizi - Director Engineer of Zhejiang Economic & Information Commission Zhang Jinyao - Senior Engineer of Zhejiang Radio Communication Province Information Industry Department, Ningbo Radio Management Office Yang Fang - Deputy Director, Senior Engineer.teams more effectively.' Research saw the white van man voted the most feared driver on the road - scarier than young drivers, elderly drivers or motorcylists. And statistics released last year by the Institute of Transport Management showed one in three company drivers have a crash annually.

The figure was even higher for those driving more.m high profile speakers including the Minister for the Marine & Natural Environment, Huw Irranca -Davies MP and Jonathan Porritt, Director of Forum for the Future. Baroness Barbara Young, Member of the Government's Climate Change Adaptation Sub -Committee and former CEO of the Environment Agency will give the keynote speech at the gala dinner.a as 'Punk Rock ECO design”. The Gateshead firm, launched in 2006, has already gained world -wide recognition for its innovation and Eco credentials and has now signed up to UK Trade & Investment’s Passport to Export scheme in a bid to explore new markets. Richard Liddle, founder and Managing Director of Cohda Design, explains.king about what's available in terms of kitchen and bathroom appliances, fixtures and fittings, was - prior to my involvement in KBZine - decades behind the reality. Although I've not been able to get out and about as much as I'd have liked to (although that's about to change - watch this space!) I've tried to get myself up to speed and had thou.sting and potential trade customers to come and visit its team 'at home' in the company's new custom -built UK distribution centre and showroom during a special 'Open Week'. The 2700 sq.ft.

Showroom in Radlett, Hertfordshire, displays the complete Blanco range and all the new products for 2010, including the very latest sink designs, a wide variety. Online bed specialist, The Sleep Room, offers a range of glamorous, retro -inspired beds for stylish sleepers. Nostalgia is a big theme for 2010 but it's often difficult to pull -off this look with modern products. Whilst vintage beds look great they rarely offer maximum comfort - are you really willing to put style before sleep? With the 'R.he tap spout. The eLIX also has a click valve which can be used to give the water a temporary boost - for example when filling a kettle.

ELIX, along with the Elio and Enya, are three tap styles that offer these performance benefits for CSH. ELIX is available in chrome and is part of Carron Phoenix's Developer range.

This commercially focussed co.s further enhanced by subtle pearlescent particles, with the beautifully smooth surface. Metallic -based worksurfaces are one of the hottest design themes around and the three finishes offer a contemporary neutral palette of Black, Chocolate and Caramel that have been researched to design well with classic and contemporary kitchen styles. The.12 months include: Big Red Sales, D.A.D, Digital Radio Development Bureau, Digitaltvinfo.com, Kodak - Tetenal, Midwich, Euro Digital Services, Humax Electronics Co., LG Electronics UK, Philex Electronic, The Sirius Buying Group and Technisat Digital UK.[TRIMTO] Retra also welcomed: Vogel's Products UK, Sennheiser UK, Top Level Solutions, VDC Tec.n 2009, Pegler Yorkshire has expanded the range further with the introduction of two new tap ranges - Ebro and Pulsar. Both are minimalistic in style and despite being part of the Francis Pegler range are competitive in price. Ebro is a fresh new design and named after the largest river in Spain, it has an unashamedly European vogue - a flow straig. MGA Distributors has been chosen as the UK's first distributor of the new Europa -2 drawer from Indaux.

Indaux has been creating, developing, manufacturing and marketing fittings and components for the furniture industry since 1962. The Europa -2 drawer demonstrates Indaux's knowledge of its market and customers' needs. The complete one -p. Recession -hit small businesses are actively managing their cash flow yet struggling to access finance because they are not presenting their management accounts in the correct format to the finance and credit industry. The news follows the latest research from the Forum of Private Business, commissioned by CreditPal, the free accounts analysis s. The Myers Touch, Dobsons Home improvements, Tradex and KCA.

This course is approved by the KBB NTG - as well as by CITB Construction Skills who sent delegate Gerald Kelly on the course. He commented: 'I enjoyed the course which was very well presented and very interesting.' Full details of training courses from Graham Hayden can be found on his. Getting the New Year off to the very best of starts with the launch of its latest product brochure - Bathroom Culture.

In full -colour throughout, the brochure has an impressive 260 pages packed with full details on the manufacturer's complete portfolio of products, printed on heavy -weight stock to lend it the quality feel which has become synon.liances etc. And is designed to stimulate the economy while saving energy and encouraging recycling - thus helping the environment. Seems like a good idea to me. The 'cash for appliance clunkers' rebate programme has a pot of $300m.

Those taking advantage of the scheme can be awarded up to $200 for the purchase of an energy efficient appliance. Siamp managing director Stuart Lorne took part in the eight day Enduro Africa Challenge, a 1500 -mile off -road motorcycle trip along South Africa’s rugged Wild Coast, to raise money for the Nelson Mandela Children’s Fund, Touch Africa and UNICEF. Manchester -based Siamp UK is the UK branch of the leading French sanitaryware manufa.its own'. Next week we kick off our 'rolling' preview of another much anticipated industry event - kbb Birmingham 2010, which is celebrating its 25th year at the NEC, Birmingham, from 21st -24th March.

If you're exhibiting at the show and haven't yet told us why visitors should make a point of going along to your stand, please do so quickly and.e Indesit Moon washing machine (in the 'Bathroom' category) in 2008, the 2009 award went to Hotpoint -Ariston's Quadrio fridge in the domestic appliances section. Granted by the Chicago Athenaeum - Museum of Architecture and Design together with the European Centre for Architecture, Art, Design and Urban Studies, the award was in recognition of t.e its professional opinion on the design quality of entries in 16 product categories and noted that - especially in economically uncertain times - design is a decisive factor in terms of market success and value creation, with many of the submitted products setting new benchmarks in their respective fields. According to the jury chairman Fritz F.with the promise of making great design affordable. The collection includes 'next125' and the handle -less 'nextline' range, which rival premium brands for the finish and the fixtures, but offered at a mid -market price. Each kitchen has a pure cubic shape, made possible by a depth of 575mm, which not only looks beautiful but provides additional s.d brassware, available from 1st February. First to announce is the new addition to Mereway's long -established style Aegean door style.

Aegean; (pictured) is a stylish paneled raised and fielded design that has helped Mereway cater for the traditional end of the market for many years. As this market is showing signs of strengthening, Mereway has.urnishings and are extremely robust and hard wearing. Ring the seasonal changes with colourful rugs - cool pastels for the summer, deep reds and golds for the winter. You can even tile outside as many tiles are frost resistant; but do check. Tile the floors both sides of the patio doors with the same tile and watch as the dining room passes almo. 20 -20 Fusion, the renowned developer of advanced design and visualisation software for the kitchen and bathroom industry, is delighted to announce the addition of Pilkington's to its fast -growing portfolio of manufacturer catalogues. Pilkington's will be represented across both the Fusion Bathrooms and Kitchens platforms with the inclusion of.id to be twice the heat store capacity of the cast iron used in other heat storage cookers.

The hob - comprised of two gas burners and an electric solid surface Chef's Plate, perfect for simmering, sizzling and sauteing, all powered separately from the ovens - unusually offers users the option of adjustable heat storage temperatures throughout the. A newly -established Water Intergroup in the European Parliament has started to help MEPs consider EU water policies more horizontally, as the European Commission prepares to put its water strategies in line with climate and resource -efficiency policies. 'Adaptation to climate change, risks of flooding and water scarcity will be on the agenda, a.ew additions from the Zehnder range. Bisque, acquired by ZGUK in 2007, will continue to offer design -led products to premium showrooms under its own brand name. 'Zehnder and Bisque will complement each other perfectly in their respective markets,' explains Allan Jones, Head of ZGUK Retail Division. 'By optimising the synergies of these two stron.

20 -20 Fusion, the design and visualisation software specialist, is delighted to announce the appointment of Jade Allen as its new Area Sales Manager for the North of England. Jade comes from a sales background, having worked for a Manchester -based PR agency where she learned the value of nurturing strong business relationships with clients and.s enables Keller to improve the performance level in terms of better products and services in a cost -effective manner; important in these challenging times. 'The union with Bruynzeel will help Keller to increase its competitive power and to establish growth in the fast -moving and widespread European kitchen industry.

Equally importantly, the fut.r and historical parkland of Hensol Castle Estate. Beautifully designed and located within an estate -managed development, these homes promise much from the outside and then deliver more from the inside with so many bespoke design features. The apartments are all furnished with Franke sinks, taps, waste disposal units and cooker hoods. MHS Radiators has launched the Zero range of low cost, lightweight aluminium radiators with contemporary styling and excellent heat outputs from 423W to 3,068W.

They make an excellent alternative to steel panel radiators and thanks to their low water content heat up rapidly and are extremely efficient.

Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Original Article Quadrivalent Vaccine against Human Papillomavirus to Prevent Anogenital Diseases Suzanne M. Garland, M.D., Mauricio Hernandez-Avila, M.D., Cosette M.

Wheeler, Ph.D., Gonzalo Perez, M.D., Diane M. Harper, M.D., M.P.H., Sepp Leodolter, M.D., Grace W.K.

Tang, M.D., Daron G. Ferris, M.D., Marc Steben, M.D., Janine Bryan, Ph.D., Frank J. Taddeo, Ph.D., Radha Railkar, Ph.D., Mark T.

Esser, Ph.D., Heather L. Sings, Ph.D., Micki Nelson, B.S., John Boslego, M.D., Carlos Sattler, M.D., Eliav Barr, M.D., and Laura A. Koutsky, Ph.D., for the Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators N Engl J Med 2007; 356:1928-1943 DOI: 10.1056/NEJMoa061760. Methods In this randomized, placebo-controlled, double-blind trial involving 5455 women between the ages of 16 and 24 years, we assigned 2723 women to receive vaccine and 2732 to receive placebo at day 1, month 2, and month 6.

The coprimary composite end points were the incidence of genital warts, vulvar or vaginal intraepithelial neoplasia, or cancer and the incidence of cervical intraepithelial neoplasia, adenocarcinoma in situ, or cancer associated with HPV type 6, 11, 16, or 18. Data for the primary analysis were collected for a per-protocol susceptible population of women who had no virologic evidence of HPV type 6, 11, 16, or 18 through 1 month after administration of the third dose. Results The women were followed for an average of 3 years after administration of the first dose. In the per-protocol population, those followed for vulvar, vaginal, or perianal disease included 2261 women (83%) in the vaccine group and 2279 (83%) in the placebo group. Those followed for cervical disease included 2241 women (82%) in the vaccine group and 2258 (83%) in the placebo group. Vaccine efficacy was 100% for each of the coprimary end points. In an intention-to-treat analysis, including those with prevalent infection or disease caused by vaccine-type and non–vaccine-type HPV, vaccination reduced the rate of any vulvar or vaginal perianal lesions regardless of the causal HPV type by 34% (95% confidence interval [CI], 15 to 49), and the rate of cervical lesions regardless of the causal HPV type by 20% (95% CI, 8 to 31).

Figure 2 Times to End-Point Events in the Intention-to-Treat Population. Of the women who underwent randomization, 2672 of 2723 subjects in the vaccine group received at least 1 dose and had at least one follow-up visit for the analysis for external anogenital end-point events and 2669 of 2732 subjects in the placebo group received at least 1 dose and had at least one follow-up visit for the analysis for external anogenital end-point events; 2609 subjects in the vaccine group and 2615 subjects in the placebo group received at least one dose of vaccine or placebo and had at least one follow-up visit for the analysis of cervical end-point events. I bars represent confidence intervals. CIN denotes cervical intraepithelial neoplasia. Anogenital infection with the human papillomavirus (HPV) can cause warts, intraepithelial neoplasia, and invasive cancers. The majority of HPV-associated diseases are caused by HPV types 6, 11, 16, and 18.

HPV types 6 (HPV-6) and 11 (HPV-11) cause most anogenital warts, a portion of the cases of low-grade neoplasia, and recurrent respiratory papillomatosis, a rare but potentially life-threatening disease. HPV type 16 (HPV-16) is the most common cause of invasive cancers of the cervix and other anogenital cancers associated with HPV. HPV type 18 (HPV-18), the second most common cause of cervical cancer, is detected even more frequently in adenocarcinoma, the incidence of which is increasing.

The precursor lesion of adenocarcinoma is difficult to detect on routine Papanicolaou testing or colposcopy. A phase 3 trial of the efficacy and safety of a quadrivalent HPV vaccine (targeting HPV-6, HPV-11, HPV-16, and HPV-18) was designed to include an intensive schedule of visits and aggressive regimens to identify cases of genital disease associated with HPV in the study population. Study Design The Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I study is an ongoing, double-blind, placebo-controlled, randomized trial sponsored by Merck; the study was designed and managed and the results were analyzed by the sponsor in conjunction with external academic investigators and an external data and safety monitoring board. From January 2002 through March 2003, 6463 women underwent screening for eligibility; of these, we enrolled a total of 5455 (84%) subjects between the ages of 16 and 24 years at 62 study sites in 16 countries. The institutional review board at each site approved the protocol.

Written informed consent was obtained from each subject. The study population was drawn primarily from communities near universities.

Healthy women who were not pregnant and had no history of genital warts or abnormal results on cervical cytologic testing and had a lifetime number of no more than four sex partners were eligible. The women were required to use effective contraception during the vaccination period (day 1 through month 7) of the study. The sponsor collated the data and monitored the conduct of the study. The cutoff date for this manuscript was June 15, 2006. The sponsor and the academic authors proposed the statistical analyses, which were performed by the sponsor. All authors had full access to these analyses and approved the final manuscript.

The manuscript was drafted by employees of the sponsor in collaboration with academic authors. All authors vouch for the completeness and accuracy of the data presented. Vaccine and Randomization The quadrivalent HPV-6/11/16/18 L1 virus-like–particle vaccine with amorphous aluminum hydroxyphosphate sulfate (Gardasil, Merck) as an adjuvant and the aluminum-containing placebo were visually indistinguishable and have been described elsewhere. A description of the randomization procedure used in the trial can be found in the, available with the full text of this article at www.nejm.org. Vaccine or placebo was administered after a negative result on a pregnancy test of the urine or blood. The women were observed for 30 minutes after vaccination. Each woman recorded oral temperatures on a vaccination report card 4 hours after receiving the injection and once daily for the next 4 days.

Adverse events were recorded with the use of the vaccination report cards for 15 days after vaccination, as were all serious adverse events potentially related to the procedure or vaccine, deaths, and pregnancy outcomes throughout the trial. Follow-up At day 1 (the day of the first injection of vaccine or placebo), month 7 (1 month after administration of the third dose), and months 12, 24, 36, and 48, the women underwent a gynecologic examination.

At day 1, month 3 (1 month after administration of the second dose), and months 7, 12, 18, 24, 30, 36, and 48, they underwent a comprehensive anogenital examination at which an endocervical and ectocervical swab specimen (considered to be one specimen), a combined labial–vulvar–perineal swab specimen, and a perianal swab specimen (pooled as one specimen) were collected. For a description of the anti-HPV testing and HPV DNA testing, see the. At day 1 and months 7, 12, 18, 24, 30, 36, and 48, cervical samples for Papanicolaou cytologic testing (ThinPrep, Cytyc) were collected. Lesions Each study site was provided with a detailed protocol describing the anogenital examination, which included visual inspection of the perianal, vulvar, and vaginal areas observed with the unaided eye, a magnifying glass, or a colposcope. Overt lesions were photographed. Biopsy specimens of lesions considered to be clinically associated with HPV or of unknown cause were obtained.

Repeated biopsy of recurrent external anogenital or vaginal lesions was not performed. The treatment of lesions was based on local standards of care. Cervical cytologic specimens were classified according to the Bethesda system (2001) and read at a central laboratory (Diagnostic Cytology Laboratories). For the criteria for referral for colposcopy, see the. All biopsy specimens were processed independently to avoid contamination of HPV DNA and were read in a blinded fashion first for clinical management by pathologists at the central laboratory, then for end-point adjudication by a panel of four gynecologic pathologists, as described in the report by the FUTURE II study group elsewhere in this issue of the Journal. Case Definition and Primary Hypotheses There were two efficacy hypotheses. The first stated that, as compared with placebo, the quadrivalent vaccine reduces the combined incidence of anogenital warts, vulvar or vaginal intraepithelial neoplasia grades 1 to 3, or cancer associated with vaccine-type HPV; the second stated that, as compared with placebo, the quadrivalent vaccine reduces the combined incidence of cervical intraepithelial neoplasia grades 1 to 3, adenocarcinoma in situ, or cancer associated with vaccine-type HPV.

A case was defined as a consensus diagnosis by the pathology panel of one of these end-point events, with vaccine-type HPV DNA detected in an adjacent histologic section of the same biopsy specimen (Fig. The subject and the investigator were informed of the need for further treatment if the panel rendered a more clinically significant diagnosis. Clinical impressions were recorded but were not used to determine an end point in the efficacy analysis. Statistical Analysis A fixed-event design was used for the statistical analysis. At least 38 cases of external anogenital or vaginal lesions associated with vaccine-type HPV and at least 38 cases of cervical lesions associated with vaccine-type HPV were required for the study to have 91% power to declare the vaccine efficacious against at least one of the primary composite end points with a one-sided alpha level of significance of 0.0125 (incorporating multiplicity adjustment), assuming a true vaccine efficacy of at least 80%. To reach the requisite numbers of each of the end points by month 36 in the primary analysis population, and an assumed event rate of 1% per year for each of the coprimary end points, approximately 5400 participants were required.

An analysis was conducted when 38 external anogenital and vaginal end-point events and 37 cervical end-point events had occurred (at approximately 1.5 years of follow-up after administration of the third dose, and including all data from visits occurring on or before July 15, 2005). This analysis was included in the application for vaccine licensure, which was approved by the Food and Drug Administration on June 8, 2006. The efficacy and safety analyses presented here include an additional year of follow-up from this ongoing study and data from visits that occurred on or before June 15, 2006. For each of the primary composite end points, the primary efficacy analysis ( Figure 1 Populations Included in the Efficacy Analyses. ) was conducted in the HPV-type–specific per-protocol susceptible populations, defined as subjects who were negative on polymerase-chain-reaction (PCR) analysis and serologic testing for the relevant vaccine-type HPV at enrollment, remained negative for the same vaccine-type HPV through 1 month after administration of the third dose of vaccine or placebo, received three doses of vaccine or placebo within 1 year, and did not have protocol violations. Follow-up for case ascertainment started 1 month after administration of the third dose.

An exact conditional procedure was used to evaluate vaccine efficacy, assuming that the numbers of cases in the vaccine group and the placebo group were independent Poisson random variables. A point estimate of vaccine efficacy and the 95% confidence interval (CI) were calculated on the basis of the observed split in cases between the vaccine and placebo recipients and the accrued person-time.

For subjects who had more than one end-point event, only the first event in a category was counted as a case (defined as a consensus diagnosis), but a subject with more than one end-point event could be counted in more than one category of end-point events. The analyses were performed with respect to the primary composite end points and were further characterized according to type of lesion and vaccine-type HPV. A woman who had a single lesion containing more than one vaccine-type HPV or multiple lesions of different histologic grades was counted once toward the composite end points and once toward the type-specific and lesion-specific end points. For example, for a woman found by consensus diagnosis to have a cervical intraepithelial neoplasia grade 2 lesion associated with HPV-16 at month 12, this end-point event would be counted as a case at month 12. Subsequently, the same subject may have been diagnosed with an HPV-16–associated cervical intraepithelial neoplasia grade 3 lesion and an HPV-18–associated cervical intraepithelial neoplasia grade 2 lesion at month 19.

Overall, on the basis of these consensus diagnoses, this subject would be counted once toward the primary composite end point, once toward HPV-16–associated end points, once toward HPV-18–associated end points, once toward cervical intraepithelial neoplasia grade 2, and once toward cervical intraepithelial neoplasia grade 3. A description of the two additional populations that were included in the prespecified analyses supportive of the primary analysis is shown in.

Vaccine efficacy was estimated in an unrestricted susceptible population that included all women who were negative on PCR analysis and serologic testing for the relevant vaccine-type HPV at enrollment. We also estimated vaccine efficacy in an intention-to-treat population that included all subjects who had undergone randomization, regardless of their baseline HPV status or evidence of HPV-associated anogenital disease. Follow-up for end-point ascertainment in these two additional populations started after day 1. The analyses in the intention-to-treat population evaluated vaccine efficacy against diseases associated with vaccine-type HPV and the overall effect of vaccination on the number of cases of prevalent and incident disease (caused by vaccine-type HPV or other HPV types). For the intention-to-treat analysis, the cumulative incidence distribution was computed for subjects in the vaccine and placebo groups for whom follow-up data were available and was presented graphically for the composite end points, with 95% CIs calculated at 6-month intervals.

Condenser Design Calculation Pdf Printer. Geometric mean antibody titers for vaccine-type HPV and seroconversion rates were measured in subjects included in the type-specific, per-protocol immunogenicity analysis. These subjects were members of the per-protocol population from whom serum samples had been collected during predefined periods. Adverse events were summarized as frequencies and percentages according to study group and the type of adverse event reported at all visits for the administration of a dose of vaccine or placebo. Risk differences and the associated 95% CIs were calculated by comparing the vaccine and placebo groups for all vaccination visits. A 95% CI (unadjusted for multiplicity testing) that does not include 0 indicates a nominally significant difference at an alpha level of 0.05 (two-sided). Results From January 2002 through March 2003, a total of 6463 women between the ages of 16 and 24 years were screened for eligibility at 62 study sites in the Asia–Pacific region, Europe, and North, Central, and South America. Of these women, 5455 met the inclusion criteria, and 2723 women were randomly assigned to receive quadrivalent vaccine and 2732 were assigned to receive placebo.

Only a small percentage (8 of 5388 subjects [0.15%]) had serologic evidence or HPV DNA evidence of infection with all the HPV types covered by the quadrivalent vaccine ( Table 1 Baseline Characteristics of the Subjects. The two study groups were well balanced with regard to baseline characteristics and were also similar in the numbers of subjects excluded from the populations analyzed. Subjects in whom vaccine-type HPV was detected at baseline were excluded from the analyses for prophylactic efficacy ( Table 2 Subjects Included in and Excluded from the Different Analyses. Subjects in this ongoing trial were followed for an average of 3 years after administration of the first dose of vaccine or placebo. At least 83% of those who underwent randomization were included in one or more of the type-specific, per-protocol susceptible populations for external anogenital or vaginal lesions (2261 subjects in the vaccine group and 2279 in the placebo group).

The HPV vaccine was 100% effective (95% CI, 94 to 100; 0 cases in the vaccine group vs. 60 cases in the placebo group) in preventing vaginal, vulvar, perineal, and perianal intraepithelial lesions or warts in association with vaccine-type HPV. In the type-specific, per-protocol susceptible populations, in the analysis for cervical end points, among 2241 subjects in the vaccine group and 2258 in the placebo group, the vaccine was 100% effective (95% CI, 94 to 100; 0 vs. 65 cases, respectively) in preventing cervical intraepithelial neoplasia of grades 1 to 3 or adenocarcinoma in situ in association with vaccine-type HPV ( Table 3 Vaccine Efficacy against External Anogenital, Vaginal, and Cervical Lesions Associated with HPV-6, HPV-11, HPV-16, or HPV-18 or Regardless of HPV Type. The estimates of vaccine efficacy made on the basis of the diagnoses at the central laboratory were similar to the estimates made by the pathology panel (data not shown).

More than 95% of the subjects who underwent randomization were included in one or more of the type-specific, unrestricted susceptible populations. The vaccine efficacy was 95% when all grades of external anogenital or vaginal lesions were combined (4 cases in the vaccine group vs. 81 cases in the placebo group), 98% when all grades of cervical lesions were combined (2 vs.

89 cases, respectively), with an efficacy of 91% for high-grade vulvar or vaginal lesions (1 vs. 11 cases, respectively), and 100% for adenocarcinoma in situ (0 vs. 6 cases, respectively) ( ). Overall, more than 95% of the subjects received the complete regimen of three doses of vaccine or placebo. Because the public health benefit of a safe and effective HPV vaccine will be measured by its effect in all vaccinated women, we estimated vaccine efficacy in an intention-to-treat population, regardless of the baseline HPV status of the subjects included in the analysis ( ). The analysis included women with prevalent infections with vaccine-type HPV or diseases associated with these HPV types.

The efficacy against vaccine-type HPV was 73% (95% CI, 58 to 83) when all grades of external anogenital or vaginal lesions were combined (28 cases in the vaccine group vs. 102 cases in the placebo group) and 55% (95% CI, 40 to 66) when all grades of cervical lesions were combined (71 vs. 155 cases, respectively) ( ). In the intention-to-treat population, in the placebo group, the incidence of external anogenital or cervical disease associated with vaccine-type HPV continued to increase over time, whereas in the vaccine group the incidence began to plateau ( Figure 2 Times to End-Point Events in the Intention-to-Treat Population. Of the women who underwent randomization, 2672 of 2723 subjects in the vaccine group received at least 1 dose and had at least one follow-up visit for the analysis for external anogenital end-point events and 2669 of 2732 subjects in the placebo group received at least 1 dose and had at least one follow-up visit for the analysis for external anogenital end-point events; 2609 subjects in the vaccine group and 2615 subjects in the placebo group received at least one dose of vaccine or placebo and had at least one follow-up visit for the analysis of cervical end-point events.

I bars represent confidence intervals. CIN denotes cervical intraepithelial neoplasia. There was no clear evidence that vaccination altered the course of disease or infection present before administration of the first dose (Table 2 in the ). No cancers associated with any vaccine-type HPV were identified. A second intention-to-treat analysis in the population of all women who underwent randomization was performed to evaluate the effectiveness of the vaccine against all anogenital disease (i.e., caused by either a vaccine-type HPV or one not covered by the vaccine). For the primary composite disease end points, in the vaccine group there was a reduction of 34% (95% CI, 15 to 49; 104 cases in the vaccine group vs. 157 cases in the placebo group) in the incidence of external anogenital or vaginal lesions and a reduction of 20% (95% CI, 8 to 31; 344 vs.

421 cases, respectively) in cervical lesions, regardless of the causal HPV type ( and ). For each HPV type covered by the quadrivalent vaccine, at least 99.5% of the subjects in the respective per-protocol immunogenicity cohort had seroconversion at 1 month after the third dose. (For details on the persistence of immune titers, see the.) Five of six recipients of the quadrivalent vaccine in the unrestricted susceptible population who had a genital lesion associated with vaccine-type HPV had antibody titers for an anti-HPV response that were similar to the corresponding anti-HPV antibody response in the per-protocol immunogenicity population.

The sixth subject had incorrectly received three doses of placebo. Vaccine recipients (87%) were more likely than placebo recipients (77%) to have adverse events at the injection site, the most common of these being pain at the site (risk difference, 10 percentage points; 95% CI, 7.8 to 12.1).

Erythema, pruritus, and swelling at the injection site were also more common among vaccine recipients than among placebo recipients ( Table 4 Adverse Events. With respect to systemic adverse events, a nominally higher proportion of vaccine recipients (13.3%), as compared with placebo recipients (10.3%), reported fever between 100°F (37.8°C) and 102°F (38.9°C) (risk difference, 3.0; 95% CI, 1.3 to 4.8) ( ).

Similar proportions of vaccine and placebo recipients reported a serious adverse event. All systemic and serious adverse events, categorized according to organ system and treatment group, are shown in Tables 3 and 4 in the. Among the subjects who were seropositive for one or more of the four HPV types at day 1, the profile of adverse events was similar to that of the entire study cohort. For example, of 529 vaccine recipients, 452 (85%) reported one or more injection-site adverse events, as compared with 388 of 507 placebo recipients (77%), with injection-site pain reported as the most frequent adverse event in 84% of the vaccine recipients and 74% of the placebo recipients (risk difference, 10.1; 95% CI, 5.2 to 15.1) ( ). One subject in this subgroup had a serious vaccine-related adverse event (bronchospasm 1 day after receipt of the third dose). No multiplicity adjustments were made for these comparisons. For a summary of the pregnancy outcomes in the combined phase 3 quadrivalent vaccine studies, see the report by the FUTURE II study group (and Tables 2, 3, and 4 in that article's Supplementary Appendix).

Discussion These results of the FUTURE I study show that a prophylactic quadrivalent HPV vaccine is highly effective in preventing clinical disease, including anogenital warts and intraepithelial neoplasia of the cervix, vagina, and vulva, associated with HPV-6, HPV-11, HPV-16, and HPV-18. There appears to be no interference among the four HPV types covered by the vaccine, since 100% HPV-type–specific efficacy was observed in the per-protocol analysis. There were relatively few adverse events among the vaccine recipients. Several steps were taken to ensure that this study would provide a high level of confidence in the safety and efficacy of the quadrivalent vaccine. A diverse population of young women participating in developed and developing countries were enrolled. Data on serious vaccine-related or procedure-related adverse events and pregnancy outcomes were collected for the entire follow-up period.

Since HPV-associated vaginal and vulvar lesions may have an ambiguous clinical presentation, an intensive visit schedule with aggressive regimens for genital inspection, biopsy of suspect lesions and cytologic screening, and colposcopy with biopsy were used to ensure a high sensitivity for HPV-associated lesions. High diagnostic accuracy for end-point determinations was provided by a panel of expert pathologists who were unaware of the treatment assignments. Estimates of vaccine efficacy were high whether the diagnoses were made by the pathology panel or by the central laboratory, indicating robust efficacy measurements. When we evaluated the quadrivalent vaccine's effectiveness against disease associated with the HPV types covered by the vaccine in the intention-to-treat population (as compared with the unrestricted susceptible population), all additional cases detected in the vaccine group occurred in subjects who were infected with vaccine-type HPV before vaccination. Among all randomized subjects with an end-point event within the first year of follow-up, both the vaccine group (57 [97%] cases of disease in 59 subjects) and the placebo group (59 [81%] cases of disease in 73 subjects) had evidence of infection or disease that was prevalent at enrollment.

During the second year of follow-up, the incidence of disease associated with vaccine-type HPV in the placebo group continued to increase, whereas in the vaccine group the incidence appeared to reach a plateau, as cases of disease due to prevalent infection were no longer detected and vaccine appeared to reduce the incidence of new infections and associated disease. A decrease (unadjusted for multiplicity) in overall rates of anogenital disease, regardless of causal HPV type, was also observed. The development of vulvar cancer, though rare, in one subject in the vaccine group highlights the importance of continued screening. Since vaccinated women remain at risk for cervical and genital disease resulting from infections with vaccine-type HPV that might be present at the time of vaccination and from newly acquired infections with HPV types that are not targeted by the quadrivalent HPV vaccine, such women should continue to undergo regular cervical screening for cancer and genital examination, as clinically indicated. A limitation of our study is the lack of long-term follow-up. The duration of the efficacy of the quadrivalent HPV vaccine and whether boosters are needed are not known. Similarly, to date, no minimum protective anti-HPV antibody titers have been identified.

A phase 2 trial of the quadrivalent vaccine showed that at 5 years the vaccine is highly efficacious against infection and disease associated with vaccine-type HPV and that vaccine-induced anti-HPV antibody levels are maintained at or above the levels observed in natural infection. At 5 years in this phase 2 study, an antigen challenge resulted in strong anamnestic responses, with sharp rises in antibody titer, indicating the presence of strong, long-lived immune memory. The FUTURE I study had limited power to definitively address individual components of the composite study end points; however, the consistency of the results for all components and the results of the FUTURE II study are encouraging. As in other trials of prophylactic vaccines, our primary analysis focused on women who at baseline were not infected with vaccine-type HPV. Under conditions that may reflect deviations in vaccine dosing intervals, such as in the unrestricted susceptible population, the efficacy against these HPV types remained high — 95% for external anogenital or vaginal lesions and 98% for cervical lesions. These data also suggest that there is some flexibility in the timing of the vaccination regimen.

Adolescent men and women mount higher antibody responses to the quadrivalent vaccine than do young adult women, but whether the quadrivalent HPV vaccine will prevent genital infection and lesions in men is unknown. Our data demonstrate the efficacy of a prophylactic quadrivalent HPV vaccine against lesions caused by all the targeted types of HPV. There was also a reduction in the overall incidence of anogenital lesions in the vaccine group. Widespread vaccination of young women and adolescent girls should reduce the incidence of cervical and external anogenital disease associated with HPV-6, HPV-11, HPV-16, and HPV-18. Further research is needed to evaluate the effect of large-scale vaccination programs on the overall burden of HPV disease. Supported by Merck Research Laboratories, a division of Merck, which funded the study in its entirety. Garland reports receiving advisory board fees and grant support from Commonwealth Serum Laboratories and GlaxoSmithKline and lecture fees from Merck; Dr.

Hernandez-Avila, consulting and advisory board fees and grant support from Merck; Dr. Wheeler, grant support from Merck and GlaxoSmithKline; Dr. Perez, consulting fees, advisory board fees, and lecture fees from Merck; Dr. Koutsky, grant support from Merck; Dr. Harper, consulting fees, advisory board fees, lecture fees, and grant support from Merck and GlaxoSmithKline; Dr. Ferris, advisory board fees, lecture fees, and grant support from Merck and consulting fees and grant support from GlaxoSmithKline; and Dr.

Steben, consulting fees, advisory board fees, and lecture fees from Digene, Merck Frosst, GlaxoSmithKline, and Roche Diagnostics and grant support from Merck Frosst and GlaxoSmithKline. Bryan, Taddeo, Railkar, Esser, Sings, Nelson, Boslego, Sattler, and Barr report being current or former employees of Merck Research Laboratories, a division of Merck, and owning stock or holding stock options, or both, in the company. No other potential conflict of interest relevant to this article was reported. References • 1 Endo M, Yamashita T, Jin HY, Akutsu Y, Jimbow K. Detection of human papillomavirus type 16 in bowenoid papulosis and nonbowenoid tissues. Int J Dermatol 2003;42:474-476 • 2 Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV.

The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002;55:244-265 • 3 Goodman A. Primary vaginal cancer. Surg Oncol Clin N Am 1998;7:347-361 • 4 Jones RW, Baranyai J, Stables S. Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. Obstet Gynecol 1997;90:448-452 • 5 Gissmann L, zur Hausen H. Partial characterization of viral DNA from human genital warts (condylomata acuminata).

Int J Cancer 1980;25:605-609 • 6 Jones RW, Rowan DM, Stewart AW. Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women. Obstet Gynecol 2005;106:1319-1326 • 7 Koutsky L. Epidemiology of genital human papillomavirus infection. Am J Med 1997;102:3-8 • 8 Feoli-Fonseca JC, Oligny LL, Brochu P, Simard P, Falconi S, Yotov WV. Human papillomavirus (HPV) study of 691 pathological specimens from Quebec by PCR-direct sequencing approach.

J Med Virol 2001;63:284-292 • 9 Bosch FX, de Sanjose S. Human papillomavirus and cervical cancer-burden and assessment of causality. J Natl Cancer Inst Monogr 2003;31:3-13 • 10.